2

Du J^#, Li S, Su Y, Wang H, Liu H, Cui H*. The role of extracellular matrix metalloproteinase inducer on the action of dihydrotestosterone against the cellular damage induced by Aβ42. Molecular and Cellular Endocrinology. 2019, 498:110536.

3

Guo G^#, Kang L, Geng D, Han S, Li S, Du J, Wang C, Cui H*. Testosterone modulates structural synaptic plasticity of primary cultured hippocampal neurons through ERK-CREB signalling pathways. Molecular and Cellular Endocrinology. 2019, 503:110671.

4

Zhang LN, Hao L, Guo YS, Wang HY, Li LL, Liu LZ, Li WB*(李文斌). Are glutamate transporters neuroprotective or neurodegenerative during cerebral ischemia? J Mol Med, 2019, 97:281-289 (SCI, IF4.746)

5

Zhao CC, Jiang MY, Zhang LY, Hu YY, Hu ZJ, Zhang MY, Qi J, Su AC, Lou N, Xian XH, Zhang JG, Li WB, Zhang M*(张敏). Peroxisome proliferator-activated receptor gamma participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via glial glutamate transporter 1 in vivo and in vitro. J Neurochem, 2019 (SCI, IF 4.87)

6

Zhang LY, Hu YY, Zhao CC, Qi J, Su AC, Lou N, Zhang MY, Li L, Xian XH, Gong JX, Zhao H, Zhang JG, Li WB, Zhang M*（张敏）. The mechanism of GLT-1 mediating cerebral ischemic injury depends on the activation of p38 MAPK. Brain Research Bulletin, 2019, 147:1-13 (SCI, IF 3.44)

7

Guoliang Zhang, Yunxiao Kang, Xu Feng, Rui Cui, Qiqing Guo, Xiaoming Ji, Yuanxiang Huang, Yannan Ma, Shufeng Liu, Geming Shi. LncRNAs Down-Regulate Myh1, Casr, and Mis18a Expression in the Substantia Nigra of Aged Male Rats. Aging (Albany NY). 2019, 11(19), 8313-28. DOI: 10.18632/aging.102321

8

Guoliang Zhang, Rui Cui, Yunxiao Kang, Chunxiao Qi, Xiaoming Ji, Tianyun Zhang, Qiqing Guo, Huixian Cui, Geming Shi. Testosterone Propionate Activated the Nrf2-ARE Pathway in Ageing Rats and Ameliorated the Age-Related Changes in Liver. Sci Rep. 2019, 9(1), 18619. DOI: 10.1038/s41598-019-55148-0

9

Xi Wang^#, Zi Xiu^#, Yuru Du, Yiming Li, Juxiang Yang, Yuan Gao, Fangfang Li, Xi Yin^*, Haishui Shi^*. Brazilin inhibits H₂O₂ induced oxidative stress and produces antidepressant- and anxiolytic-like effects in mice. Biol. Pharm. Bull. 2019,42(8), 1268–1274 (IF= 1.694)

10

Xumeng Ji^#, Luling Shi^#, Xi Yin^#, Ziqing Huai, Yiming Li, Jingyi Ren, Yuanyuan Fu, Yuru Du, Yuan Gao, Li Song^*, Haishui Shi^**. Sex- and developmental stage-dependent effects of fluorene-9-bisphenol exposure on emotional behaviors in mice. Chemosphere. 2019,225, 890-896 (IF= 5.108)

11

Yuru Du^#, Wenjing Li^#, Yiming Li, Juxiang Yang, Xinhao Wang, Shuo Yin, Xi Wang, Omar Israel Velez de-la-Paz, Yuan Gao, Haiying Chen, Xi Yin^*, HaishuiShi^*. Repeated arctigenin treatment produces antidepressant- and anxiolytic-like effects in mice. Brain Res Bull. 2019，146：79-86 (IF= 3.44)

12

Yin S, Shao J, Wang XH, Yin X, Li WJ, Gao Y, Velez de-la-Paz  OI, Shi HS*, Li SC*. Methylene blue exerts rapid neuroprotective effects on lipopolysaccharide-induced behavioral deficits in mice. Behav Brain Res. 2019, 356:288-294 (IF= 3.173)

13

Fu, C., Shi, L., Wei, Z., Yu, H., Hao, Y., Tian, Y., Liu, Y., Zhang, Y., Zhang, X., Yuan, F., and Wang, S. (2019) Activation of Phox2b-Expressing Neurons in the Nucleus Tractus Solitarii Drives Breathing in Mice. J Neurosci 39, 2837-2846

14

Zhang F, Wang Y, Liu Y, Han H, Zhang D, Fan X, Du X, Gamper N, Zhang H. Transcriptional Regulation of Voltage-Gated Sodium Channels Contributes to GM-CSF-Induced Pain. J Neurosci. 2019 Jun 26;39(26):5222-5233.

15

 Zhang F, Wang Y, Liu Y, Han H, Zhang D, Fan X, Du X, Gamper N, Zhang H. (2019) Transcriptional Regulation of Voltage-Gated Sodium Channels Contributes to GM-CSF-Induced Pain.J Neurosci. 39:5222-33.

16

Zhang F, Gigout S, Liu Y, Wang Y, Hao H, Buckley NJ, Zhang H, Wood IC, Gamper N. (2019) Repressor element 1-silencing transcription factor drives the development of chronic pain states.PAIN 160:2398-2408

17

Li C, Zou R, Zhang H, Wang Y, Qiu B, Qiu S, Wang W, Xu Y. Upregulation of phosphoinositide 3-kinase prevents sunitinib-induced cardiotoxicity in vitro and in vivo. Arch Toxicol. 2019 Jun;93(6):1697-1712.

18

Shen L, Li C, Zhang H, Qiu S, Fu T, Xu Y. Downregulation of miR-146a Contributes to Cardiac Dysfunction Induced by the Tyrosine Kinase Inhibitor Sunitinib. Front Pharmacol. 2019 Aug 23;10:914. doi: 10.3389/fphar.2019.00914. eCollection 2019.

19

Qiu B, Wang Y, Li C, Guo H, Xu Y. Utility of the JT Peak Interval and the JT Area in Determining the Proarrhythmic Potential of QT-Shortening Agents. J Cardiovasc Pharmacol Ther. 2019; 24(2): 160-171.

20

Guanhua Zhang, Hongxia Wang, Wenyu Xie, Qi Wang, Xu Wang, Chunying Wang, Yingfeng Du, Changhong Huo, Qiao Wang*. Comparison of triterpene compounds of four botanical parts from Poria cocos (Schw.) wolf using simultaneous qualitative and quantitative method and metabolomics approach. Food Research International, 2019,121:666-677.

21

Xiyan Mu, Chuanyuan Ji, Qi Wang, Kun Liu, Xinyu Hao, Guanhua Zhang,Xiaowei Shi, Yuqian Zhang, Frank J. Gonzalez, Qiao Wang*., Yangang Wang**. Non-targeted metabolomics reveals diagnostic biomarker in thetongue coating of patients with chronic gastritis. Journal of Pharmaceutical and Biomedical Analysis,2019,174: 541-551.

22

Xiaochen Liu, Xueyan Fan, Xin Wang, Ruina Liu, Caifeng Meng, Chunying Wang*.Structural characterization and Screening of Chemical Markers of Flavonoids in Lysimachiae Herba and Desmodii Styracifolii Herba by ultra high-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry based metabolomics approach. Journal of Pharmaceutical and Biomedical Analysis 2019,171:52-64.

23

Xueyan Fan, Xiaochen Liu, Caifeng Meng, Ruina Liu, Zijian Zhang，Chunying Wang*，Metabolites study on 5-O-methylvisammioside in vivo and in vitro by ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry，Journal of Separation Science,2019,42(12):2107-2114.

24

Wang S, Geng Q, Huo L, Ma Y, Gao Y, Zhang W, Zhang H, Lv P*, Jia Z*. Transient Receptor Potential Cation Channel Subfamily Vanilloid 4 and 3 in the Inner Ear Protect Hearing in Mice. Front Mol Neurosci. 2019, Accept. (IF: 3.72).

25

Han Y, Liu C, Zhang D, Men H, Huo L, Geng Q, Wang S, Gao Y, Zhang W, Zhang Y, Jia Z*. Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle. Int J Oncol. 2019, 55(3): 629-644. (IF: 3.57).

26

Yanyan Zhu*, JingWang*, A non enzymatic amperometric glucose sensor based on the use of graphene frameworks-promoted ultrafine platinum nanoparticle，A non- s，Microchimica Acta，0026-3672， 2019, 186, 538-547，IF：5.479，JCR 1区

27

Yulong Lin, Meng Li*, Jing Wang*, Targeted acetylcholinesterase-responsive drug carriers with long duration of drug action and reduced hepatotoxicity，International Journal of Nanomedicine，1178-2013，2019:14 5817–5829，IF：4.7，JCR 1区

28

Hu Q, Wang Q, Wang C#, Tai Y, Liu B, Shao X, Fang J, Liu B. TRPV1 Channel Contributes to the Behavioral Hypersensitivity in a Rat Model of Complex Regional Pain Syndrome Type 1. Front Pharmacol. 2019 Apr 26;10:453. eCollection (# 通讯作者, IF: 3.845) (SCI二区)

29

Zheng X, Tai Y, He D, Liu B, Wang C, Shao XM, Jordt SE, Liu B. ETAR and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: a molecular mechanism of ET-1-induced mechanical hyperalgesia. Mol Pain. 2019 Apr 16:1744806919842473. ( IF: 3.2) (SCI三区)

30

JintuoYin, Yinling Ma, Caijuan Liang, Jin Gao, HairongWang,Lantong Zhang*. A systematic study on the metabolites of dietary acacetin in vivo and in vitro based on UHPLC-Q-TOF-MS/MS analysis. Journal of Agricultural and Food Chemistry, 2019, 67,5530-5543. IF=3.412.

31

 Luya Li , Yuting Chen, Xue Feng , Jintuo Yin , Shenghao Li , Yupeng Sun , Lantong Zhang*. A comprehensive metabolism profiling of eupatorin in vivo and in vitro based on UHPLC-Q-TOF-MS/MS combined with an efficient data acquisition and processing method. Molecules, 2019,24,2658. IF=3.098.

32

Luya Li, Xue Feng, Yuting Chen, Shenghao Li, Yupeng Sun, and Lantong Zhang*. A comprehensive study of eriocitrin metabolism in vivo and in vitro based on an efficient UHPLC-Q-TOF-MS/MS strategy. RSC Advances, 2019, 9, 24963-24980. IF=3.108.

33

Yuting Chen, Xue Feng, Luya Li, Xiaowei Zhang, Kewei Song, Xinpeng Diao,Yupeng Sun, Lantong Zhang*. UHPLC-Q-TOF-MS/MS method based on four-step strategy formetabolites of hinokiflavone in vivo and in vitro. Journal of Pharmaceutical and Biomedical Analysis，2019,169, 19-29. IF=2.831.

34

12. Yingfeng Du，Ludan Hou，Chen Chu, Yiran Jin, Wenjing Sun, Rong Zhang. Characterization of serum metabolites as biomarkers of carbon black nanoparticles-induced subchronic toxicity in rats by hybrid triple quadrupole time-of-flight mass spectrometry with non-targeted metabolomics strategy. Toxicology, 2019.07. IF= 3.547.

35

13. Ludan Hou, Shuai Guan, Yiran Jin, Wenjing Sun, Qiao Wang, Yingfeng Du*.Cell metabolomics to study the cytotoxicity of carbon black nanoparticles on A549 cells using UHPLC-Q/TOF-MS and multivariate data analysis，Science of the Total Environment，2019. IF= 5.589.

36

Yiran Jin, Tingting Tian, Yinghua Ma, Ludan Hou, Shuai Guan, Wenjing Sun, Yingfeng Du*  Lantong Zhang. Chemical profiling and total quality assessment of Isodon japonica using data-independent acquisition mode combined with superimposed multiple product ion UHPLC-Q-TOF-MS and chemometric analysis. RSC Advances, 2019.02. IF= 3.049.

37

Ludan Hou, Yiran Jin, Wenjing Sun, Shuai Guan, Huijun Xu, Qiao Wang, Lantong Zhang, Yingfeng Du*.Metabolites identification of (+)-usnic acid in vivo by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Fitoterapia, 2019.03. IF= 2.431.

38

Fan Zhang, Yiying Wang, Yu Liu, Hao Han, Dandan Zhang, Xizhenzi Fan, Xiaona Du, Nikita Gamper, Hailin Zhang. Transcriptional regulation of voltage-gated sodium channels contributes to GM-CSF-induced pain. The Journal of Neuroscience, 2019.  (IF 6.07)

39

Fan Zhang, Yani Liu, Feng Tang, Bo Liang, Huanming Chen, Hailin Zhang, Kewei Wang. Electrophysiological and pharmacological characterization of a novel and potent neuronal Kv7 channel opener SCR2682 for anti-epilepsy. The FASEB Journal, 2019.  (IF 5.59)

40

Fan Zhang, Sylvain Gigout, Yu Liu, Yiying Wang, Han Hao, Noel J. Buckley, Hailin Zhang, Ian C. Wood, Nikita Gamper. Repressor element 1-silencing transcription factor drives the development of chronic pain states. Pain, 2019. (IF 6.03)

41

Fan Zhang, Yani Liu, Dandan Zhang, Xizhenzi Fan, Decheng Shao, Han Li. Suppression of KCNQ/M potassium channel in dorsal root ganglia neurons contributes to the development of osteoarthritic pain. Pharmacology 2019. （IF 1.67）

42

Wang S, Geng Q, Huo L, Ma Y, Gao Y, Zhang W, Zhang H, Lv P*, Jia Z*. Transient Receptor Potential Cation Channel Subfamily Vanilloid 4 and 3 in the Inner Ear Protect Hearing in Mice. Front in Molecular Neurosci 2019 (accepted)

43

Shao P, Guo N, Wang C, Zhao M, Yi L, Liu C, Kang L, Cao L, Lv P, Xing L, Zhang X, Shen H. Aflatoxin G1 induced TNF-α-dependent lung inflammation to enhance DNA damage in alveolar epithelial cells. J Cell Physiol. 2019 Jun;234(6):9194-9206. 

44

Yulong Lin, Yalin Wang, Jie Lv, Nannan Wang, Jing Wang, Meng Li*. Targeted acetylcholinesterase-responsive drug carriers with long duration of drug action and reduced hepatotoxicity. International journal of nanomedicine 2019, 14, 5817.

45

Shuangling Wang, Han Yan, Yalin Wang, Na Wang, Yulong Lin, Meng Li*. Hollow Prussian Blue nanocubes as peroxidase mimetic and enzyme carriers for colorimetric determination of ethanol. Microchim Acta 2019, 186, 738.

46

Lin Liu, Chenxi Liang, Xiaowei Wang, Xiayu Ding, Yingjing Lu, Jinghui Dong, Mei Han, Hongyuan Yang, Mingming Gao*, Jiawei Liao*, Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR-/- mice fed on high-fat diet. Scientific Reports. 2019 Nov 28;9(1):17848. DOI: 10.1038/s41598-019-54392-8

47

Mingming Gao*, Xun Huang, Baoliang Song, Hongyuan Yang*,The Biogenesis of lipid droplets: Lipids take center stage. Prog Lipid Res. 2019 Jul;75:100989. DOI: 10.1016/j.plipres.2019.100989

48

Wang F，Wang J，Zhao T，Zhang Y，Li Q*. CB2 receptor agonist JWH133 activates AMPK to inhibit growth of C6 glioma cells. Open Life Sci. 2019; 14: 363–375. (IF1.0)

49

Wang W, Zheng J, Cui N, Jiang L, Zhou H, Zhang D, Hao G*. Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinase. J Ovarian Res. 2019 Nov 13;12(1):109. (IF 2.46)

50

Cui N, Li AM, Luo ZY, Zhao ZM, Xu YM, Zhang J, Yang AM, Wang LL, Hao GM*, Gao BL.  Effects of growth hormone on pregnancy rates of patients with thin endometrium. J Endocrinol Invest. 2019 Jan;42(1):27-35. (IF 2. 6)

51

Xu X, Liu Q , Zhang C , Ren S, et al.  Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence. Cell Death and Disease ( 2019) 10:282 (IF 6.187 )

52

Zhao Y^#, Liu XH^#, Qu Y, Wang LX, Geng D, Chen W, Li L, Tian YY, Chang SY, Zhao CF, Zhao XJ*, Lv P*. The role of p38 MAPK→COX2 and NF-κB→COX2 signaling pathways in age-related testosterone reduction, Sci Rep, 2019, 9:10556. DOI: 10.1038/s41598-019-46794-5

53

Runjiao Zhang, Yan Li, Qing Liu, Yanjing Gao, Juan Du, Jun Ma, Shaoguang Sun, Lei Wang. Differential expression profiles and functional prediction of circular RNAs and long noncoding RNAs in the hippocampus of Nrf2-knockout mice. Front Mol Neurosci. 2019, 12, 196. DOI: 10.3389/fnmol.2019.00196

54

Peng Kong, Yuan Yu, Lu Wang, Yongqing Dou, Xuhui Zhang, Yan Cui, Hai-yue Wang, Yutao Yong, Yabin Liu, Haijuan Hu, Wei Cui, Shaoguang Sun, Binghui Li, Fan Zhang, Mei Han. circ-Sirt1 controls NF-κB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle cells. Nucleic Acids Res. 2019, 47(7):3580-3593. DOI: 10.1093/nar/gkz141

55

Xinghua Li, Junjie Miao, Zhendong Yin, Xiangdong Xu, Hongmei Shi*.Polypyrrole-Modified Nylon 6 Nanofibers as Adsorbent for the Extraction of Two β-Lactam Antibiotics in Water Followed by Determination with Capillary Electrophoresis. Molecules . 2019, 24, 2198; 1-16.

56

Yaxian Pang, Boyuan Zhang, Dongmei Xing, Jinmei Shang, Fengge Chen, Hui Kang, Chen Chu, Binghua Li, Juan Wang, Lixiao Zhou, Xuan Su, Bin Han, Jie Ning, Peiyuan Li, Shitao Ma, Dong Su, Rong Zhang *, Yujie Niu **. Increased risk of carotid atherosclerosis for long-term exposure to indoor coal-burning pollution in rural area, Hebei Province, China. Environmental Pollution 255 (2019) 113320 (SCI, IF=5.714)

57

Bin Han, Chen Chu, Xuan Su, Ning Zhang, Lixiao Zhou, Mengyue Zhang, Shuaishuai Yang, Lei Shi, Bo Zhao, Yujie Niu, Rong Zhang* N6-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKTmTOR pathway drove the development of pulmonary fibrosis induced by nanoscale carbon black particles in rats. Nanotoxicology. 2019.1661041 (SCI, IF=5.955)

58

Yingfeng Du, Ludan Hou, Chen Chu, Yiran Jin, Wenjing Sun, Rong Zhang⁎. Characterization of serum metabolites as biomarkers of carbon black nanoparticles-induced subchronic toxicity in rats by hybrid triple quadrupole time-of-flight mass spectrometry with non-targeted metabolomics strategy. Toxicology 426 (2019) 152268 （SCI, IF=3.547）

59

5. Jie Ning, Peiyuan Li, Boyuan Zhang, Bin Han, Xuan Su, Qian Wang, Xiurong Wang, Binghua Li, Hui Kang, Lixiao Zhou, Chen Chu, Ning Zhang, Yaxian Pang, Yujie Niu, Rong Zhang*. miRNAs deregulation in serum of mice is associated with lung cancer related pathway deregulation induced by PM2.5. Environmental Pollution 254 (2019) 112875 （SCI, IF=5.714）

60

Chen Chu,# Lixiao Zhou,# Heran Xie,# Zijie Pei, Mengyue Zhang, Mengqi Wu, Shaohui Zhang, Luqi Wang, Chunfang Zhao, Lei Shi, Ning Zhang, Yujie Niu, Yuxin Zheng, Rong Zhang*. Pulmonary toxicities from a 90-day chronic inhalation study with carbon black nanoparticles in rats related to the systemical immune effects，International Journal of Nanomedicine 2019:14 2995–3013. （SCI, IF=4.471）

61

Daochuan Li#, Rong Zhang#, Lianhua Cui, Chen Chu, Haiyan Zhang, Hao Sun, Jing Luo, Lixiao Zhou, Liping Chen, Jian Cui, Shen Chen, Bixian Mai, Shejun Chen, Jianzhen Yu, Zongwei Cai, Jianqing Zhang, Yousheng Jiang, Michael Aschner, Rui Chen, Yuxin Zheng, Wen Chen, Multiple organ injury in male C57BL/6J mice exposed to ambient particulate matter in a real-ambient PM exposure system in Shijiazhuang, China. Environmental Pollution 248 (2019) 874-887. （SCI, IF=5.7）

62

Chen Chu, Haiya Zhang, Shijie Cui, Bin Han, Lixiao Zhou, Ning Zhang, Xuan Su, Yujie Niu, Wen Chen, Rui Chen, Rong Zhang⁎, Yuxin Zheng，Ambient PM2.5 caused depressive-like responses through Nrf2/NLRP3 signaling pathway modulating inflammation，Journal of Hazardous Materials 369 (2019) 180–190. （SCI, IF=7.650）

63

Lixiao Zhou, Xuan Su, Binghua Li, Chen Chu, Hongyue Sun, Ning Zhang, Bin Han, Chen Li, Bingjie Zou, Yujie Niu, Rong Zhang*, PM2.5 exposure impairs sperm quality through testicular damage dependent on NALP3 inflammasome and miR-183/96/182 cluster targeting FOXO1 in mouse. Ecotoxicology and Environmental Safety. 2019, 169: 551-563.（SCI, IF=4.527）