一、PI简介
石葛明，教授，博士生导师。主要从事雄激素、氧化应激与衰老及衰老相关神经退行性变的研究。主持完成国家自然科学基金课题2项及河北省自然科学基金课题6项，参与完成国家自然科学基金课题3项。研究课题“非荧光双标记的建立及其在神经解剖学研究中的应用”获卫生部科学技术进步三等奖，发表科研论文80余篇。自2011年以来以通讯作者发表SCI收录论文16篇。培养博士生9人、硕士生13人。作为第4~6版的编委、第7版的副主编参与了人民卫生出版社出版的《医用局部解剖学》教材的编写；作为编委参与了人民卫生出版社出版的《现代神经生物学》、《人体解剖学》和《临床应用神经解剖学》专著的编写。
二、研究方向
（一）雄激素、氧化应激与神经退行性变
（二）单胺神经体系与神经发育障碍性疾病
三、代表性论文
1 | Guoliang Zhang, Geming Shi, Huibing Tan, Yunxiao Kang, Huixian Cui. Intranasal administration of testosterone increased immobile-sniffing, exploratory behavior, motor behavior and grooming behavior in rats. Horm Behav. 2011, 59(4), 477-83. DOI: 10.1016/j.yhbeh.2011.01.007 |
2 | Rui Cui, Guoliang Zhang, Yunxiao Kang, Qinglong Cheng, Huibing Tan, Huixian Cui, Geming Shi. Amelioratory Effects of Testosterone Propionate Supplement on Behavioral, Biochemical and Morphological Parameters in Aged Rats. Oncotarget. Exp Gerontol. 2012, 47(1), 67-76. DOI: 10.1016/j.exger.2011.10.009 |
3 | Guoliang Zhang, Wei Wang, Yunxiao Kang, Yan Xue, Huan Yang, Chenming Zhou, Geming Shi. Chronic Testosterone Propionate Supplement Could Activated the Nrf2-ARE Pathway in the Brain and Ameliorated the Behaviors of Aged Rats. Behav Brain Res. 2013, 252, 388-95. DOI: 10.1016/j.bbr.2013.05.063 |
4 | Peng Wang, Wenjuan Bao, Guoliang Zhang, Huixian Cui, Geming Shi. Transmembrane-4-L-six-family-1, a Potential Predictor for Poor Prognosis, Overexpressed in Human Glioma. Neuroreport. 2015, 26(8), 455-61. DOI: 10.1097/WNR.0000000000000370 |
5 | Wensheng Yan, Jie Kang, Guoliang Zhang, Shuangcheng Li, Yunxiao Kang, Lei Wang, Geming Shi. The Effects of Gonadectomy and Binge-Like Ethanol Exposure During Adolescence on Open Field Behaviour in Adult Male Rats. Neurosci Lett. 2015, 14, 604:52-7. DOI: 10.1016/j.neulet.2015.07.039 |
6 | Guoliang Zhang, Shuangcheng Li, Yunxiao Kang, Jing Che, Rui Cui, Shuang Song, Huixian Cui, Geming Shi. Enhancement of Dopaminergic Activity and Region-Specific Activation of Nrf2-ARE Pathway by Intranasal Supplements of Testosterone Propionate in Aged Male Rats. Horm Behav. 2016, 80, 103-16. DOI: 10.1016/j.yhbeh.2016.02.001 |
7 | Li Wang, Yunxiao Kang, Guoliang Zhang, Yingbo Zhang, Rui Cui, Wensheng Yan, Huibing Tan, Shuangcheng Li, Baiyila Wu, Huixian Cui, Geming Shi. Deficits in Coordinated Motor Behavior and in Nigrostriatal Dopaminergic System Ameliorated and VMAT2 Expression Up-Regulated in Aged Male Rats by Administration of Testosterone Propionate. Exp Gerontol. 2016, 78, 1-11. DOI: 10.1016/j.exger.2016.03.003 |
8 | Yunxiao Kang, Wensheng Yan, Hui Fang, Guoliang Zhang, Yakun Du, Lei Wang, Huixian Cui, Geming Shi. Alleviation of oxidative damage and involvement of Nrf2-ARE pathway in mesodopaminergic system and hippocampus of Status Epilepticus rats pretreated by intranasal pentoxifylline. Oxid Med Cell Longev. 2017, 2017, 7908072. DOI: 10.1155/2017/7908072 |
9 | Rui Cui, Yunxiao Kang, Li Wang, Shuangcheng Li, Xiaoming Ji, Wensheng Yan, Guoliang Zhang, Huixian Cui, Geming Shi. Testosterone Propionate Exacerbates the Deficits of Nigrostriatal Dopaminergic System and Downregulates Nrf2 Expression in Reserpine-Treated Aged Male Rats. Front Aging Neurosci. 2017, 9, 172. DOI: 10.3389/fnagi.2017.00172 |
10 | Wensheng Yan, Yunxiao Kang, Xiaoming Ji, Shuangcheng Li, Yingkun Li, Guoliang Zhang, Huixian Cui, Geming Shi. Testosterone Upregulates the Expression of Mitochondrial ND1 and ND4 and Alleviates the Oxidative Damage to the Nigrostriatal Dopaminergic System in Orchiectomized Rats. Oxid Med Cell Longev. 2017, 2017, 1202459. DOI: 10.1155/2017/1202459 |
11 | Li Li, Yunxiao Kang, Xiaoming Ji, Yingkun Li, Shuangcheng Li, Xiangjian Zhang, Huixian Cui, Geming Shi. Finasteride Inhibited Brain Dopaminergic System and Open-Field Behaviors in Adolescent Male Rats. CNS Neurosci Ther. 2018, 24(2), 115-25. DOI: 10.1111/cns.12781 |
12 | Chunxiao Qi, Xiaoming Ji, Guoliang Zhang, Yunxiao Kang, Yuanxiang Huang, Rui Cui, Shuangcheng Li, Huixian Cui, Geming Shi. Haloperidol Ameliorates Androgen-Induced Behavioral Deficits in Developing Male Rats. J Endocrinol. 2018, 237(2), 193-205. DOI: 10.1530/JOE-17-0642 |
13 | Guoliang Zhang, Yunxiao Kang, Chenming Zhou, Rui Cui, Min Jia, Shen Hu, Xiaoming Ji, Jiayu Yuan, Huixian Cui , Geming Shi. Amelioratory Effects of Testosterone Propionate on Age-related Renal Fibrosis via Suppression of TGF-β1/Smad Signaling and Activation of Nrf2-ARE Signaling. Sci Rep. 2018, 8(1), 10726. DOI: 10.1038/s41598-018-29023-3 |
14 | Guoliang Zhang, Yunxiao Kang, Xu Feng, Rui Cui, Qiqing Guo, Xiaoming Ji, Yuanxiang Huang, Yannan Ma, Shufeng Liu, Geming Shi. LncRNAs Down-Regulate Myh1, Casr, and Mis18a Expression in the Substantia Nigra of Aged Male Rats. Aging (Albany NY). 2019, 11(19), 8313-28. DOI: 10.18632/aging.102321 |
15 | Guoliang Zhang, Rui Cui, Yunxiao Kang, Chunxiao Qi, Xiaoming Ji, Tianyun Zhang, Qiqing Guo, Huixian Cui, Geming Shi. Testosterone Propionate Activated the Nrf2-ARE Pathway in Ageing Rats and Ameliorated the Age-Related Changes in Liver. Sci Rep. 2019, 9(1), 18619. DOI: 10.1038/s41598-019-55148-0 |
16 | Tianyun Zhang, Yu Wang, Yunxiao Kang, Li Wang, Hui Zhao, Xiaoming Ji, Yuanxiang Huang, Wensheng Yan, Rui Cui, Guoliang Zhang, Geming Shi. Testosterone Enhances Mitochondrial Complex V Function in the Substantia Nigra of Aged Male Rats. Aging (Albany NY). 2020, 12. DOI: 10.18632/aging.103265 |
四、团队现有承担课题情况
雄激素改善衰老过程神经元线粒体的功能障碍及TFAM参与的相关机制研究。国家自然科学基金面上项目（2019.01-2022.12），主持人石葛明。
五、团队人员
（一）张国梁，副教授，硕士生导师。主要研究方向为衰老的神经解剖和神经生物学。主持国家自然科学基金青年基金1项和河北省教育厅青年基金1项，参与国家自然科学基金2项。发表科研论文25篇，其中SCI论文8篇。
（二）康云霄，副教授。主要研究方向为氧化应激与神经退行性变，发表SCI论文6篇。主持省级课题1项，参与国家自然科学基金3项。在“心力衰竭时糖皮质激素的促利尿机制及临床应用”中作为第三完成人获得河北省医学科技奖一等奖。
（三）崔瑞，副教授。主要研究方向为雄激素与神经退行性疾病，发表SCI收录论文6篇，主持省级课题1项，厅级课题1项，参与国家自然科学基金3项。
