一、PI简介
张荣，教授，医学博士，博士研究生导师。现任mg游戏平台电子手机版下载卫生毒理学教研室主任，兼任中国毒理学会理事，中国环境诱变剂学会理事，中华预防医学会卫生毒理学分会委员，中国毒理学会工业毒理专业委员会常务委员，中国环境诱变剂学会生物标志专业委员会常务委员/中国毒理学会神经毒理专业委员会、生化与分子生物学专业委员会、毒理教育委员会委员，河北省预防医学会卫生毒理专业委员会主任委员，河北省毒理学会常务委员，河北省环境诱变剂学会常务理事等。主要研究方向环境毒理学与环境流行病学。先后主持国家自然科学基金重大研究计划1项，面上项目3项，青年基金1项，中国博士后基金1项，河北省自然科学基金2项，以及多项其他省部级科研项目。获得河北省科技进步三等奖1项、河北省医学科技一等奖1项。荣获mg游戏平台电子手机版下载“十一五”科技工作先进个人、“十二五”期间优秀教学个人。主编《持久性有机污染物与健康》，参编“十三五”规划本科教材《职业卫生与职业医学》、研究生教材《分子毒理学》，其他教材和论著10部，科研结果发表在PFT、Journal of Hazardous Materials等毒理学杂志上，近来发表科研论文50余篇，在毒理学研究领域取得了一定的成果。
二、研究方向
方向(一)
环境毒理学：针对环境中常见的污染物开展毒理学研究，本方向受到国家自然科学基金重大研究计划1项，面上项目4项课题资助。
方向(二)
环境流行病学：针对环境污染物对健康的影响开展人群队列研究，本方向受到国家自然科学基金面上项目1项、科技部重大专项1项课题资助。
三、代表性论文
1 | Lixiao Zhou, Peiyuan Li, Mengyue Zhang, Bin Han, Chen Chu, Xuan Su, Binghua Li, Hui Kang, Jie Ning, Boyuan Zhang, Shitao Ma, Dong Su, Yaxian Pang, Yujie Niu, Rong Zhang*. Carbon black nanoparticles induce pulmonary fibrosis through NLRP3 inflammasome pathway modulated by miR-96 targeted FOXO3a. Chemosphere. 241 (2020) 125075 (SCI, IF=5.108) |
2 | Yaxian Pang, Boyuan Zhang, Dongmei Xing, Jinmei Shang, Fengge Chen, Hui Kang, Chen Chu, Binghua Li, Juan Wang, Lixiao Zhou, Xuan Su, Bin Han, Jie Ning, Peiyuan Li, Shitao Ma, Dong Su, Rong Zhang *, Yujie Niu **. Increased risk of carotid atherosclerosis for long-term exposure to indoor coal-burning pollution in rural area, Hebei Province, China. Environmental Pollution 255 (2019) 113320 (SCI, IF=5.714) |
3 | Bin Han, Chen Chu, Xuan Su, Ning Zhang, Lixiao Zhou, Mengyue Zhang, Shuaishuai Yang, Lei Shi, Bo Zhao, Yujie Niu, Rong Zhang* N6-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKTmTOR pathway drove the development of pulmonary fibrosis induced by nanoscale carbon black particles in rats. Nanotoxicology. 2019.1661041 (SCI, IF=5.955) |
4 | Yingfeng Du, Ludan Hou, Chen Chu, Yiran Jin, Wenjing Sun, Rong Zhang⁎. Characterization of serum metabolites as biomarkers of carbon black nanoparticles-induced subchronic toxicity in rats by hybrid triple quadrupole time-of-flight mass spectrometry with non-targeted metabolomics strategy. Toxicology 426 (2019) 152268 （SCI, IF=3.547） |
5 | 5. Jie Ning, Peiyuan Li, Boyuan Zhang, Bin Han, Xuan Su, Qian Wang, Xiurong Wang, Binghua Li, Hui Kang, Lixiao Zhou, Chen Chu, Ning Zhang, Yaxian Pang, Yujie Niu, Rong Zhang*. miRNAs deregulation in serum of mice is associated with lung cancer related pathway deregulation induced by PM2.5. Environmental Pollution 254 (2019) 112875 （SCI, IF=5.714） |
6 | Chen Chu,# Lixiao Zhou,# Heran Xie,# Zijie Pei, Mengyue Zhang, Mengqi Wu, Shaohui Zhang, Luqi Wang, Chunfang Zhao, Lei Shi, Ning Zhang, Yujie Niu, Yuxin Zheng, Rong Zhang*. Pulmonary toxicities from a 90-day chronic inhalation study with carbon black nanoparticles in rats related to the systemical immune effects，International Journal of Nanomedicine 2019:14 2995–3013. （SCI, IF=4.471） |
7 | Daochuan Li#, Rong Zhang#, Lianhua Cui, Chen Chu, Haiyan Zhang, Hao Sun, Jing Luo, Lixiao Zhou, Liping Chen, Jian Cui, Shen Chen, Bixian Mai, Shejun Chen, Jianzhen Yu, Zongwei Cai, Jianqing Zhang, Yousheng Jiang, Michael Aschner, Rui Chen, Yuxin Zheng, Wen Chen, Multiple organ injury in male C57BL/6J mice exposed to ambient particulate matter in a real-ambient PM exposure system in Shijiazhuang, China. Environmental Pollution 248 (2019) 874-887. （SCI, IF=5.7） |
8 | Chen Chu, Haiya Zhang, Shijie Cui, Bin Han, Lixiao Zhou, Ning Zhang, Xuan Su, Yujie Niu, Wen Chen, Rui Chen, Rong Zhang⁎, Yuxin Zheng，Ambient PM2.5 caused depressive-like responses through Nrf2/NLRP3 signaling pathway modulating inflammation，Journal of Hazardous Materials 369 (2019) 180–190. （SCI, IF=7.650） |
9 | Lixiao Zhou, Xuan Su, Binghua Li, Chen Chu, Hongyue Sun, Ning Zhang, Bin Han, Chen Li, Bingjie Zou, Yujie Niu, Rong Zhang*, PM2.5 exposure impairs sperm quality through testicular damage dependent on NALP3 inflammasome and miR-183/96/182 cluster targeting FOXO1 in mouse. Ecotoxicology and Environmental Safety. 2019, 169: 551-563.（SCI, IF=4.527） |
10 | Linpeng Niu, Mengjiao Shao, Yuan Liu, Jinfeng Hu, Ruofan Li, Heran Xie, Lixiao Zhou, Lei Shi, Rong Zhang *, Yujie Niu*. Reduction of oxidative damages induced by titanium dioxide nanoparticles correlates with induction of the Nrf2 pathway by GSPE supplementation in mice. Chemico-Biological Interactions 275 (2017) 133-144. （SCI, IF=3.296） |
11 | Rong Zhang, Zijie Pei, Yuxin Zheng. The pulmonary toxicity in nanoscale carbon black-exposed workers. Toxicology Letters, 2016，258s: S54（SCI, IF=3.858）. |
12 | Zhiqin Shi, Yujie Niu, Qian Wang, Lei Shi, Huicai Guo, Yi Liu, Yue Zhu, Shufeng Liu, 12. Chao Liu, Xin Chen, Rong Zhang*. Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo. Journal of Hazardous Materials 298 (2015) 310–319. （SCI, IF=6.069） |
13 | Rong Zhang, Yufei Dai, Xiao Zhang, Yong Niu, Tao Meng, Yuanyuan Li, Huawei Duan, Ping Bin, Meng Ye, Xiaowei Jia, Meili Shen, Shanfa Yu, Xiaofa Yang, Weimin Gao and Yuxin Zheng. Reduced pulmonary function and increased pro-inflammatory cytokines in nanoscale carbon black-exposed workers, Particle and Fibre Toxicology 2014, 11:73.（SCI, IF=7.11） |
14 | Rong Zhang, Sanjay Premi, Sarah S. Kilic, Antonella Bacchiocchi, Ruth Halaban and Douglas E. Brash. Clonal growth of human melanocytes using cell-free extracellular matrix. Pigment cell & melanoma research, 2013, 26(6): 925-927（SCI, IF=5.839） |
15 | Longgang Fan, Yujie Niu, Shaohui Zhang, Leishi, Huicai Guo, Yi Liu, Rong Zhang*. Development of a screening system for DNA damage and repair of potential carcinogens based on dual luciferase assay in human HepG2 cell. Mutagenesis. 2013, 28(5): 515–524.(SCI, IF=3.5) |
16 | Yujie Niu, Xing Zhang, Yuxin Zheng, Rong Zhang*. XRCC1 deficiency increased the DNA damage induced by γ-ray in HepG2 cell: Involvement of DSB repair and cell cycle arrest. Environmental Toxicology and Pharmacology. 2013,36:311-319.(SCI, IF=2.005) |
17 | Zhang R, Niu Y, Zhou Y. Increase the cisplatin cytotoxicity and cisplatin-induced DNA damage in HepG2 cells by XRCC1 abrogation related mechanisms. Toxicol Lett. 2010, 192:108-114. (SCI, IF=3.479) |
18 | Zhang R, Lu H, Tian S, Yin J, Chen Q, Ma L, Cui S, Niu Y. Protective effects of pre-germinated brown rice diet on low levels of Pb-induced learning and memory deficits in developing rat. Chem Biol Interact. 2010，184:484–491. (SCI, IF=3.077) |
19 | Zhang R, Niu Y, Du H, Cao X, Shi D, Hao Q, Zhou Y. A stable and sensitive testing system for potential carcinogens based on DNA damage-induced gene expression in human HepG2 cell. Toxicol In Vitro, 2009, 23:158–165. (SCI, IF=2.473) |
20 | Chen Q, Niu Y, Zhang R*, Guo H, Gao Y, Li Y, Liu R. The toxic influence of paraquat on hippocampus of mice: involvement of oxidative stress. Neurotoxicology, 2010, 31:310-316（通讯作者，SCI, IF=2.918） |
21 | Zhang R, Niu Y, Li Y, Zhao C, Song B, Li Y, Zhou Y. Acute toxicity study of the interaction between titanium dioxide nanoparticles and lead acetate in mice. Environmental Toxicology and Pharmacology, 2010, 30(1):52-60. (SCI, IF=2.005) |
1. Lixiao Zhou, Peiyuan Li, Mengyue Zhang, Bin Han, Chen Chu, Xuan Su, Binghua Li, Hui Kang, Jie Ning, Boyuan Zhang, Shitao Ma, Dong Su, Yaxian Pang, Yujie Niu, Rong Zhang*. Carbon black nanoparticles induce pulmonary fibrosis through NLRP3 inflammasome pathway modulated by miR-96 targeted FOXO3a. Chemosphere. 241 (2020) 125075 (SCI, IF=5.108)
2. Yaxian Pang, Boyuan Zhang, Dongmei Xing, Jinmei Shang, Fengge Chen, Hui Kang, Chen Chu, Binghua Li, Juan Wang, Lixiao Zhou, Xuan Su, Bin Han, Jie Ning, Peiyuan Li, Shitao Ma, Dong Su, Rong Zhang *, Yujie Niu **. Increased risk of carotid atherosclerosis for long-term exposure to indoor coal-burning pollution in rural area, Hebei Province, China. Environmental Pollution 255 (2019) 113320 (SCI, IF=5.714)
3. Bin Han, Chen Chu, Xuan Su, Ning Zhang, Lixiao Zhou, Mengyue Zhang, Shuaishuai Yang, Lei Shi, Bo Zhao, Yujie Niu, Rong Zhang* N6-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKTmTOR pathway drove the development of pulmonary fibrosis induced by nanoscale carbon black particles in rats. Nanotoxicology. 2019.1661041 (SCI, IF=5.955)
4. Yingfeng Du, Ludan Hou, Chen Chu, Yiran Jin, Wenjing Sun, Rong Zhang⁎. Characterization of serum metabolites as biomarkers of carbon black nanoparticles-induced subchronic toxicity in rats by hybrid triple quadrupole time-of-flight mass spectrometry with non-targeted metabolomics strategy. Toxicology 426 (2019) 152268 （SCI, IF=3.547）
5. Jie Ning, Peiyuan Li, Boyuan Zhang, Bin Han, Xuan Su, Qian Wang, Xiurong Wang, Binghua Li, Hui Kang, Lixiao Zhou, Chen Chu, Ning Zhang, Yaxian Pang, Yujie Niu, Rong Zhang*. miRNAs deregulation in serum of mice is associated with lung cancer related pathway deregulation induced by PM2.5. Environmental Pollution 254 (2019) 112875 （SCI, IF=5.714）
6. Chen Chu,# Lixiao Zhou,# Heran Xie,# Zijie Pei, Mengyue Zhang, Mengqi Wu, Shaohui Zhang, Luqi Wang, Chunfang Zhao, Lei Shi, Ning Zhang, Yujie Niu, Yuxin Zheng, Rong Zhang*. Pulmonary toxicities from a 90-day chronic inhalation study with carbon black nanoparticles in rats related to the systemical immune effects，International Journal of Nanomedicine 2019:14 2995–3013. （SCI, IF=4.471）
Daochuan Li#, Rong Zhang#, Lianhua Cui, Chen Chu, Haiyan Zhang, Hao Sun, Jing 7. Luo, Lixiao Zhou, Liping Chen, Jian Cui, Shen Chen, Bixian Mai, Shejun Chen, Jianzhen Yu, Zongwei Cai, Jianqing Zhang, Yousheng Jiang, Michael Aschner, Rui Chen, Yuxin Zheng, Wen Chen, Multiple organ injury in male C57BL/6J mice exposed to ambient particulate matter in a real-ambient PM exposure system in Shijiazhuang, China. Environmental Pollution 248 (2019) 874-887. （SCI, IF=5.7）
8. Chen Chu, Haiya Zhang, Shijie Cui, Bin Han, Lixiao Zhou, Ning Zhang, Xuan Su, Yujie Niu, Wen Chen, Rui Chen, Rong Zhang⁎, Yuxin Zheng，Ambient PM2.5 caused depressive-like responses through Nrf2/NLRP3 signaling pathway modulating inflammation，Journal of Hazardous Materials 369 (2019) 180–190. （SCI, IF=7.650）
9. Lixiao Zhou, Xuan Su, Binghua Li, Chen Chu, Hongyue Sun, Ning Zhang, Bin Han, Chen Li, Bingjie Zou, Yujie Niu, Rong Zhang*, PM2.5 exposure impairs sperm quality through testicular damage dependent on NALP3 inflammasome and miR-183/96/182 cluster targeting FOXO1 in mouse. Ecotoxicology and Environmental Safety. 2019, 169: 551-563.（SCI, IF=4.527）
10. Linpeng Niu, Mengjiao Shao, Yuan Liu, Jinfeng Hu, Ruofan Li, Heran Xie, Lixiao Zhou, Lei Shi, Rong Zhang *, Yujie Niu*. Reduction of oxidative damages induced by titanium dioxide nanoparticles correlates with induction of the Nrf2 pathway by GSPE supplementation in mice. Chemico-Biological Interactions 275 (2017) 133-144. （SCI, IF=3.296）
11. Rong Zhang, Zijie Pei, Yuxin Zheng. The pulmonary toxicity in nanoscale carbon black-exposed workers. Toxicology Letters, 2016，258s: S54（SCI, IF=3.858）.
Zhiqin Shi, Yujie Niu, Qian Wang, Lei Shi, Huicai Guo, Yi Liu, Yue Zhu, Shufeng Liu, 12. Chao Liu, Xin Chen, Rong Zhang*. Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo. Journal of Hazardous Materials 298 (2015) 310–319. （SCI, IF=6.069）
13. Rong Zhang, Yufei Dai, Xiao Zhang, Yong Niu, Tao Meng, Yuanyuan Li, Huawei Duan, Ping Bin, Meng Ye, Xiaowei Jia, Meili Shen, Shanfa Yu, Xiaofa Yang, Weimin Gao and Yuxin Zheng. Reduced pulmonary function and increased pro-inflammatory cytokines in nanoscale carbon black-exposed workers, Particle and Fibre Toxicology 2014, 11:73.（SCI, IF=7.11）
14. Rong Zhang, Sanjay Premi, Sarah S. Kilic, Antonella Bacchiocchi, Ruth Halaban and Douglas E. Brash. Clonal growth of human melanocytes using cell-free extracellular matrix. Pigment cell & melanoma research, 2013, 26(6): 925-927（SCI, IF=5.839）
15. Longgang Fan, Yujie Niu, Shaohui Zhang, Leishi, Huicai Guo, Yi Liu, Rong Zhang*. Development of a screening system for DNA damage and repair of potential carcinogens based on dual luciferase assay in human HepG2 cell. Mutagenesis. 2013, 28(5): 515–524.(SCI, IF=3.5)
16. Yujie Niu, Xing Zhang, Yuxin Zheng, Rong Zhang*. XRCC1 deficiency increased the DNA damage induced by γ-ray in HepG2 cell: Involvement of DSB repair and cell cycle arrest. Environmental Toxicology and Pharmacology. 2013,36:311-319.(SCI, IF=2.005)
17. Zhang R, Niu Y, Zhou Y. Increase the cisplatin cytotoxicity and cisplatin-induced DNA damage in HepG2 cells by XRCC1 abrogation related mechanisms. Toxicol Lett. 2010, 192:108-114. (SCI, IF=3.479)
18. Zhang R, Lu H, Tian S, Yin J, Chen Q, Ma L, Cui S, Niu Y. Protective effects of pre-germinated brown rice diet on low levels of Pb-induced learning and memory deficits in developing rat. Chem Biol Interact. 2010，184:484–491. (SCI, IF=3.077)
19. Zhang R, Niu Y, Du H, Cao X, Shi D, Hao Q, Zhou Y. A stable and sensitive testing system for potential carcinogens based on DNA damage-induced gene expression in human HepG2 cell. Toxicol In Vitro, 2009, 23:158–165. (SCI, IF=2.473)
20. Chen Q, Niu Y, Zhang R*, Guo H, Gao Y, Li Y, Liu R. The toxic influence of paraquat on hippocampus of mice: involvement of oxidative stress. Neurotoxicology, 2010, 31:310-316（通讯作者，SCI, IF=2.918）
21. Zhang R, Niu Y, Li Y, Zhao C, Song B, Li Y, Zhou Y. Acute toxicity study of the interaction between titanium dioxide nanoparticles and lead acetate in mice. Environmental Toxicology and Pharmacology, 2010, 30(1):52-60. (SCI, IF=2.005)
四、团队现有承担课题情况
课题（一）
国家自然科学基金，81973074，N6-甲基腺苷介导靶向ALKBH2的miRNAs代谢失衡在纳米级炭黑致肺遗传损伤及肿瘤发生发展中的作用，（2020.1-2023.12），54万，张荣主持
课题（二）
生殖医学国家重点实验室开放课题，SKLRM-K201907，大气细颗粒物对雄性小鼠生殖能力的影响及机制研究，（2020.1-2021.12），经费代码：KY116XJ20190013，张荣主持
课题（三）
河北省卫生厅青年科技课题，20200865，miR_204_5p介导的Sirt1/Nrf2信号通路在纳米级碳黑颗粒诱导肺纤维化中的作用研究，王茜主持
五、团队人员
团队人员组成：宋波、闫丽娜、王茜
宋波，副教授，硕士研究生导师。研究方向为神经毒理学。以第一作者身份发表论著近20篇，其中SCI收录论文5篇。参编教材和专著2部，获得全国教育教学信息化比赛一等奖1项，全国教育教学信息化比赛二等奖1项，教育部公共卫生与预防医学委员会二等奖1项，河北省科技进步三等奖1项，河北省医学科技奖一等奖1项，河北省教育教学信息化比赛一等奖2项。
