一、PI简介
石红梅,教授,博士(三级),博士研究生导师。兼任中国检验检测学会理事、河北省检验检疫学会秘书长、河北省化学会理事等职务。主要从事卫生理化检验方法学研究,创新建立了Ag(III)/Ni(IV)配合物化学发光检测新体系,深入研究了该化学发光检测体系的反应机制,并将该体系与毛细管电泳/高效液相色谱分离技术相结合,建立了环境中抗生素残留、食品中农药残留、兽药残留、环境毒素、生化及生物标志物等的同时分离分析新方法;并进一步对环境低剂量抗生素暴露下,环境介质中耐药基因的检测、鉴定及分布等进行研究。近年来主持国家自然科学基金面上项目2项、省自然科学基金项目1项,近五年来在《Journal of Chromatography A》、《Journal of Chromatography B》、《International Journal of Molecular Sciences》、《Molecules》、《分析化学》、《Pharmaceutical and Biomedical Analysis》等期刊发表论文十余篇,其中SCI论文8篇,作为主要完成人(排名第二)获得河北省科技进步二等奖2项(2015、2018年度)。
二、研究方向
方向(一)
高效毛细管电泳分离技术用于食品安全分析和临床分析。
方向(二)
高灵敏数字PCR技术:环境中耐药基因的测定与分布分析;围绕mRNA、microRNA、lncRNAs等的表达分析;微生物(病毒、细菌等)的检测;转基因成分的检测;肿瘤治疗的实时监控与伴随诊断等。
三、代表性论文
1 | Hongmei Shi*, Likun Feng, Shigang Shen* , Weijun Kang , Hanwen Sun. A kinetic study on the oxidation of tetrahydrofurfurylamine by bis(hydrogenperiodato) argentate(III) complex anion. Polish Journal of Chemistry. 2008,82:2179-2188 . |
2 | Hongmei Shi, Xiangdong Xu, Yuexin Ding, Shipeng Liu, Liqing Li, Weijun Kang*. Determination of cortisol in human blood serums by a new Ag(III) complex- luminol chemiluminescent system. Analytical Biochemistry. 2009,387:178 (SCI 3.002). |
3 | Hongmei Shi, Weijun Kang*, Shigang Shen, Hanwen Sun. Oxidation of 3-(4-methoxyphenoxy)-1,2-propanediol by bis(hydrogen periodato)argentate(III) complex anion: a kinetic study. Transition Metal Chemistry. 2009,34:91-95. |
4 | Hongmei Shi*, Rongjian Du, Weijun Kang. DO oxidation of α-diols by bis(hydrogenperiodato) argentite(III) proceed according to different laws. Transition Metal Chemistry. 2009,34:181-184. |
5 | Hongmei Shi, Shipeng Liu, Shigang Shen, Shuying Huo and Weijun Kang*. A kinetic investigation of the oxidation of dl-pipecolinate by bis(hydrogenperiodato)argentate(III) complex anion. Transition Metal Chemistry. 2009,34(8):821-826. |
6 | Li Ma, Mengdi Fan, Xiangdong Xu, Weijun Kang, Hongmei Shi*. Utilization of a Novel Ag(III)-Luminol Chemiluminescence System for Determination of d-Penicillamine in Human Urine Samples. Journal of the Brazilian Chemical Society. 2011,22(8):1463-1469. |
7 | Hongmei Shi*, Yukun Guo, Weijun Kang. Kinetic Study of the Oxidation of N,N-Dimethylethanolamine by Bis(Hydrogenperiodato)Argentate(III) in Aqueous Solution. Journal of Solution Chemistry. 2011,40:1371-1381. |
8 | Xiao-Xin Tan1, Kao-Qi Lian1, Xiang Li, Nan Li, Wei Wang, Wei-Jun Kang, Hong-Mei Shi*.Development of a derivatization method for the quantification of hydrogensulfide and its application in vascular calcification rats. Journal of Chromatography B. 2017,1055-1056:8-14. |
9 | Xinghua Li, Junjie Miao, Zhendong Yin, Xiangdong Xu, Hongmei Shi*.Polypyrrole-Modified Nylon 6 Nanofibers as Adsorbent for the Extraction of Two β-Lactam Antibiotics in Water Followed by Determination with Capillary Electrophoresis. Molecules . 2019, 24, 2198; 1-16. |
10 | Xiao Dong, Yajie Diao, Xinghua Li, Tingting Dai, Hongmei Shi*, Shan Li*. Investigation on a Sensitive Chemiluminescence System Based on Ni(IV) Complex to Determine Two β2 -Agonist Drugs in Urine and Swine Feed and Their Mechanism. applied sciences. 2018,8:663-671. |
四、团队现有承担课题情况
课题(一)
国家自然科学基金,81773481,典型高浓度PM污染下环境介质和人体排泄物中抗生素残留的测定及耐药基因分布特征研究,(2018-2021),55万,石红梅主持
课题(二)
河北省自然科学基金,H201806279,基于化学发光和Android智能手机平台的氧化酶活性与生物分子现场快速检测新技术研究,(2018.1-2020.12),6万,徐向东主持
课题(三)
科技东奥专项,19977719D, 前沿水质检测技术在冬奥会安全保障体系中的应用研究与技术示范,(2019,7-2021.12),50万,徐向东主持
五、团队人员
团队人员:徐向东、苗俊杰、檀笑昕、马莉
徐向东,副教授,医学博士, 硕士研究生导师。主持国家自然科学基金青年基金1项、河北省博士后科研项目择优基金1项和河北省自然科学基金1项。主持国家自然科学基金青年基金,河北省博士后科研项目择优基金。主研国家自然科学基金2项。是河北省科技支撑项目计划《环境内分泌干扰物检测新方法的研究》负责人。发表SCI论文10篇、核心期刊9篇。担任全国卫生检验与检疫专业教育部统编教材《水质理化检验》(编委)和《卫生检验与检疫实验教程:理化分册》副主编。