一、PI简介
(一)武宇明简介
中国共产党党员,生理学博士,教授,博士生导师,mg游戏平台电子手机版下载副校长,兼任中国生理学会理事,河北省生理科学会理事长,担任第九版《生理学》教材副主编,教育部本科教学审核评估专家,教育部高等学校临床医学类实践教学分指导委员会委员。获得“教育部新世纪优秀人才”,“全国优秀科技工作者”,“河北省普通高等学校教学名师”,“河北省管专家”等荣誉称号。长期从事心血管生理学的研究,主要研究方向为心血管活性物质对血压稳态的调控作用。主持国家自然基金重大研究计划(培育)、国家自然基金面上项目等10余项研究课题,共获得科研经费400余万元,目前在研3项国家自然科学基金,以通讯作者发表SCI论文30篇(IF>5.0共3篇,IF>3.0共17篇),总影响因子76.4。获河北省科技进步奖二等奖1项,指导6名研究生获得河北省优秀硕士学位论文,指导本科生荣获河北省第一届大学生创新创业年会论文特等奖,河北省第三届“挑战杯”大学生课外学术科技作品竞赛一等奖。
(二)滕旭简介
民盟盟员,生理学博士、教授、硕士生导师。主要从事心血管生理学和病理生理学研究,首先发现并报道了神经调节在血管钙化中的作用,提示阻断交感神经过度兴奋可能成为血管钙化的防治策略,α受体阻断剂可能成为治疗血管钙化的有效药物。主持国家自然科学基金2项、省部级基金项目3项、其他基金项目4项,共获得科研经费140余万元;已发表SCI论文35篇,影响因子合计118,总引用644次,H-index为14,以第一作者和通讯作者发表SCI论文12篇,影响因子合计37;获河北省科技进步奖二等奖1项、中华医学科技奖三等奖1项;担任医学与健康研究院心血管中心PI、河北省实验动物重点实验室心血管方向学术带头人、河北省生理科学会理事、国家自然科学基金同行评审、Life Science等多家SCI杂志审稿人、《比较医学杂志》等中文核心期刊编委;获河北省“三三三人才”三层次人才、河北省高等学校科学研究优秀青年基金。
二、研究方向
(一)心血管活性物质对血压稳态的调控作用。
(二)神经调节在血管钙化中的作用。
三、代表性论文
(一)武宇明代表性论文
1 | Tian DY, Teng X, Jin S, Chen YH, Xue HM, Xiao L, Wu YM*. Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling. Journal of Advanced Research. available online 20 June 2020. (IF: 6.992) |
2 | Cao YK, Guo Q, Ma HJ, Wang R, Teng X, Wu YM*. Microinjection of urotensin II into the rostral ventrolateral medulla increases sympathetic vasomotor tone via the GPR14/ERK pathway in rats. Hypertens Res. 2020 May 8. (IF 2.921) |
3 | Guo Q, Feng X, Xue H, Jin S, Teng X, Duan X, Xiao L, Wu Y*. Parental Renovascular Hypertension-Induced Autonomic Dysfunction in Male Offspring Is Improved by Prenatal or Postnatal Treatment With Hydrogen Sulfide. Front Physiol. 2019 Sep 19;10:1184. (IF 3.201) |
4 | Teng X, Li H, Xue H, Jin S, Xiao L, Guo Q, Wu Y*. GABAA receptor, KATP channel and L-type Ca2+ channel is associated with facilitation effect of H2S on the baroreceptor reflex in spontaneous hypertensive rats. Pharmacol Rep. 2019 Oct;71(5):968-975. (IF 2.761) |
5 | Li J, Teng X, Jin S, Dong J, Guo Q, Tian D, Wu Y*. Hydrogen sulfide improves endothelial dysfunction by inhibiting the vicious cycle of NLRP3 inflammasome and oxidative stress in spontaneously hypertensive rats. J Hypertens. 2019 Aug;37(8):1633-1643. (IF 4.209) |
6 | Qiu X, Liu K, Xiao L, Jin S, Dong J, Teng X, Guo Q, Chen Y, Wu Y*. Alpha-lipoic acid regulates the autophagy of vascular smooth muscle cells in diabetes by elevating hydrogen sulfide level. Biochim Biophys Acta Mol Basis Dis. 2018;1864(11):3723-3738. (IF 5.108) |
7 | Xiao L, Dong JH, Teng X, Jin S, Xue HM, Liu SY, Guo Q, Shen W, Ni XC, Wu YM*. Hydrogen sulfide improves endothelial dysfunction in hypertension by activating peroxisome proliferator-activated receptor delta/endothelial nitric oxide synthase signaling. J Hypertens. 2018; 36(3): 651-665. (IF 4.099) |
8 | Chen YH, Jin S, Teng X, Hu ZJ, Zhang ZH, Qiu X, Tian DY, Wu YM*. Hydrogen Sulfide Attenuates LPS-Induced Acute Kidney Injury by Inhibiting Inflammation and Oxidative Stress. Oxid Med Cell Longev. 2018; 2018: 6717212. (IF 4.593) |
9 | Tian D, Dong J, Jin S, Teng X, Wu Y*. Endogenous hydrogen sulfide-mediated MAPK inhibition preserves endothelial function through TXNIP signaling. Free Radic Biol Med. 2017; 110: 291-299. (IF 6.02) |
10 | Guo Q, Feng X, Xue H, Teng X, Jin S, Duan X, Xiao L, Wu Y*. Maternal Renovascular Hypertensive Rats Treatment With Hydrogen Sulfide Increased the Methylation of AT1b Gene in Offspring. Am J Hypertens. 2017; 30(12): 1220-1227. (IF 3.541) |
11 | Jin S, Tan B, Teng X, Meng R, Jiao X, Tian D, Xiao L, Xue H, Guo Q, Duan X, Wu Y*. Diurnal Fluctuations in Plasma Hydrogen Sulfide of the Mice. Front Pharmacol. 2017;6;8:682. (IF 3.8) |
12 | Liu SY, Duan XC, Jin S, Teng X, Xiao L, Xue HM, Wu YM*. Hydrogen Sulfide Improves Myocardial Remodeling via Downregulated Angiotensin II/AT1R Pathway in Renovascular Hypertensive Rats. Am J Hypertens. 2017; 30(1): 67-74. (IF 3.541) |
13 | Jin S, Teng X, Xiao L, Xue H, Guo Q, Duan X, Chen Y, Wu Y*. Hydrogen sulfide ameliorated L-NAME-induced hypertensive heart disease by the Akt/eNOS/NO pathway. Exp Biol Med (Maywood). 2017; 242(18): 1831-1841. (IF 2.68) |
14 | Zhang Z, Jin S, Teng X, Duan X, Chen Y, Wu Y*. Hydrogen sulfide attenuates cardiac injury in takotsubo cardiomyopathy by alleviating oxidative stress. Nitric Oxide. 2017; 67: 10-25. (IF 4.181) |
15 | Li H, Teng X, Yang R, Guo Q, Xue H, Xiao L, Duan X, Tian D, Feng X, Wu Y*. Hydrogen Sulfide Facilitates the Impaired Sensitivity of Carotid Sinus Baroreflex in Rats with Vascular Calcification. Front Pharmacol. 2017; 8: 629. (IF 3.8) |
16 | Xiao L, Dong JH, Jin S, Xue HM, Guo Q, Teng X, Wu YM*. Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4/COX-2 Pathway in Rats with Hypertension. Oxid Med Cell Longev. 2016; 2016: 8128957. (IF 4.593) |
17 | Guo Q, Wu Y*, Xue H, Xiao L, Jin S, Wang R. Perfusion of isolated carotid sinus with hydrogen sulfide attenuated the renal sympathetic nerve activity in anesthetized male rats. Physiol Res. 2016 18; 65(3): 413-423. (IF 1.461) |
18 | Yang R, Teng X, Li H, Xue HM, Guo Q, Xiao L, Wu YM. Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress. Oxid Med Cell Longev. 2016; 2016: 9095242. (IF 4.593) |
19 | Duan XC, Guo R, Liu SY, Xiao L, Xue HM, Guo Q, Jin S, Wu Wu YM*. Gene transfer of cystathionine β-synthase into RVLM increases hydrogen sulfide-mediated suppression of sympathetic outflow via KATP channel in normotensive rats. Am J Physiol Heart Circ Physiol. 2015; 308(6): H603-611. (IF 3.324) |
20 | Duan XC, Liu SY, Guo R, Xiao L, Xue HM, Guo Q, Jin S, Wu YM*. Cystathionine-β-Synthase Gene Transfer Into Rostral Ventrolateral Medulla Exacerbates Hypertension via Nitric Oxide in Spontaneously Hypertensive Rats. Am J Hypertens. 2015; 28(9): 1106-1113. (IF 3.182) |
21 | Xue H, Zhou S, Xiao L, Guo Q, Liu S, Wu Y*. Hydrogen sulfide improves the endothelial dysfunction in renovascular hypertensive rats. Physiol Res. 2015; 64(5): 663-672. (IF 1.293) |
22 | Ji W, Liu S, Dai J, Yang T, Jiang X, Duan X, Wu Y*. Hydrogen sulfide defends against the cardiovascular risk of Nw-nitro -L-argininemethyl ester-induced hypertension in rats via the nitric oxide/endothelial nitric oxide synthase pathway. Chin Med J (Engl). 2014; 127(21): 3751-3757. (IF 1.217) |
23 | Guo Q, Jin S, Wang XL, Wang R, Xiao L, He RR, Wu YM*. Hydrogen sulfide in the rostral ventrolateral medulla inhibits sympathetic vasomotor tone through ATP-sensitive K+ channels. The Journal of pharmacology and experimental therapeutics 2011, 338(2):458-465. (IF 3.828) |
24 | Xu M, Wu YM*, LI Q, LIU S, LI Q, HE RR. Electrophysiological effects of hydrogen sulfide on human atrial fibers. Chin Med J(Engl), 2011, 21:3455-3459. (IF 0.983) |
25 | Xiao L,Wu YM*, Wang R, Liu YX, Wang FW, He RR. Hydrogen sulfide facilitates carotid sinus baroreceptor activity in anesthetized male rats. Chin Med J(Engl), 2007;120(15) :1343-1347. (IF 0.615) |
26 | Xiao L, Wu YM*, Zhang H, Liu YX, He RR. Hydrogen sulfide facilitates carotid sinus baroreflex in anesthetized rats. Acta Pharmacol Sin, 2006, 27(3):294-298. (IF 1.125) |
27 | Liu hx, Xu M, Guo Q,Xue HM,Wu YM*. Effects of hydrogen sulfide on ouabain-induced delayed afterdepolarization and triggered activity in guinea pig papillary muscles.2011,Chin Med J 91(43)3050-3053. |
28 | Xu M, Wu YM*, Li Q, Wang X, He RR. Electrophysiological effects of hydrogen sulfide on pacemaker cells in sinoatrial nodes of rabbits. Acta Physiol Sin,2008,60(2):175-180. |
29 | Xu M, Wu YM*,Li Q, Wang X, He RR.Electrophysiological effects of hydrogen sulfide on guinea pig papillary muscles in vitro. Acta Physiol Sin,2007,59(2):215-220. |
30 | Ma HJ, Liu YX, Wang FW, Wang LX, He RR, Wu YM*. Genistein inhibits carotid sinus baroreceptor activity in anesthetized male rats. Acta Pharmacol Sin. 2005 Jul;26(7):840-844. |
(二)滕旭代表性论文
四、团队现有承担课题情况
(一)国家自然基金衰老重大研究计划培育项目,91849120,2019/01-2021/12,60万元,在研,武宇明主持。
(二)国家自然科学基金面上项目,31871154, 2019/01-2022/12,60万元,在研,武宇明主持。
(三)国家自然科学基金面上项目,31671185, 2017/01-2020/12,61万元,在研,武宇明主持。
(四)国家自然科学基金面上项目,81770499,2018/01-2021/12,52万元,在研,滕旭主持。
(五)国家自然科学基金青年项目,31701008,2018/01-2020/12,25万,在研,郭琪主持。
(六)河北省重点研发计划项目,20277735D, 2020/05-2022/06,20万,在研,武宇明主持。
(七)河北省自然科学基金面上项目,H2020206350,2020/01-2022/12,10万元,在研,滕旭主持。
(八)河北省自然科学基金青年项目,H2020206313,2020/01-2022/12,6万,在研,田丹阳主持。
(九)河北省高等学校科学技术研究重点项目,ZD2019027,2019/01-2021/12,5万,在研,金胜主持。
(十)河北省高等学校青年拔尖人才计划,BJ2020041,2020/01-2022/12,9万,在研,田丹阳主持。
五、团队人员
薛红梅 香港中文大学生理学博士,南开大学博士后 副教授,硕士生导师 研究方向:心血管生理及血管生物学,尤其专长于血管内皮功能障碍的机制信号传导及药物调控 邮箱:hongmei_xue@163.com QQ:308307942 | |
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| 肖琳 mg游戏平台电子手机版下载生理学博士,美国约翰霍普金斯医学院访问学者,副教授 研究方向:心血管生理及血管生物学,尤其专长于高血压血管内皮功能障碍的机制研究 邮箱:lin_xiao@126.com QQ:12950990 |
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金胜 复旦大学生理学博士 副教授,硕士生导师 研究方向:心血管生理学,主要专注于气体信号分子的心肌保护作用机制研究 邮箱:jinshengsheng@126.com QQ:110358183 | |
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| 郭琪 mg游戏平台电子手机版下载生理学博士,美国密歇根理工大学博士后,高级实验师,硕士生导师 研究方向:心血管生理学,尤其是自主神经系统对心血管相关疾病的调控以及机制 邮箱:guoqi_hebphy@126.com QQ:158529283 |
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| 田丹阳 mg游戏平台电子手机版下载生理学博士,香港中文大学访问学者,讲师 研究方向:心血管生理及血管生物学,尤其专长于血管内皮功能障碍的机制研究 邮箱:tian1250156630@126.com QQ: 1250156630 |
孙建平 | 俞啟遥 | ||
Jianping Sun | Qiyao Yu | ||
2018级博士生 | 2018级博士生 | ||
neuro.sjp@hebmu.edu.cn | yumnn9@126.com | ||
谢奇 | 李晓阁 | ||
Qi Xie | Xiaoge Li | ||
2018级硕士生 | 2018级硕士生 | ||
1718282784@qq.com | 2820406696@qq.com | ||
| 梁子辉 |
| 秦雪元 |
Zihui Liang | Xueyuan Qin | ||
2019级博士生 | 2019级博士生 | ||
66267875@qq.com | 360665987@qq.com | ||
| 路帆 |
| 何凯传 |
Fan Lu | Kaichuan He | ||
2019级硕士生 | 2019级硕士生 | ||
930759626@qq.com | Kaichuan_He@163.com | ||
| 苗雨欣 | 于皓 | |
Yuxin Miao | Hao Yu | ||
2020级博士生 | 2020级硕士生 | ||
2391250172@qq.com | 592666117@qq.com | ||
顾笑营 | 白露 | ||
Xiaoying Gu | Lu Bai | ||
2020级硕士生 | 2020级硕士生 | ||
gxy558518@163.com | 945956629@qq.com | ||
李艳敏 | 高原 | ||
Yanmin Li | Yuan Gao | ||
2020级硕士生 | 2020级硕士生 | ||
liym22014@163.com |
六、联系我们
武宇明
Yuming Wu, Ph. D.
E mail: wuyum@yahoo.com
Phone: +86(311)-86261288
QQ: 690286835
滕旭
Xu Teng, Ph. D.
E mail: tengxu78@163.com
Phone: +86(311)-86266464
QQ: 744967521