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一、PI简介

高明明简介

2016年毕业于北京大学心血管研究所，获得生理学博士学位。现为mg游戏平台电子手机版下载基础医学研究所副教授，博士生导师。主要利用基因工程小鼠、仓鼠模型，分子及细胞生物学手段，从事糖代谢紊乱及相关疾病研究。主持国家自然科学基金面上项目1项、青年科学基金1项，河北省教育厅青年拔尖人才项目1项。以第一作者/通讯作者发表SCI论文9篇，包括Cell Research、Proc Natl Acad Sci USA、Prog Lipid Res、J Cell Biol、Arterioscler Thromb Vasc Biol、EBioMedicine、Hum Mol Genet等期刊。担任中国动脉硬化学会-RCT学组委员，河北省生物化学与分子生物学会理事。入选河北省三三三人才工程第三层次。

二、研究方向

糖脂代谢紊乱及相关疾病研究

三、代表性论文

1	Mingming Gao, Lin Liu, Xiaowei Wang, Hoi Yin Mak, George Liu, Hongyuan Yang. GPAT3 Deficiency Alleviates Insulin Resistance and Hepatic Steatosis in a Mouse Model of Severe Congenital Generalized Lipodystrophy. Hum Mol Genet. 2020* Feb 1;29(3):432-443. DOI: 10.1093/hmg/ddz300
2	Lin Liu, Chenxi Liang, Xiaowei Wang, Xiayu Ding, Yingjing Lu, Jinghui Dong, Mei Han, Hongyuan Yang, Mingming Gao, Jiawei Liao, Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR-/- mice fed on high-fat diet. Scientific Reports. 2019 Nov 28;9(1):17848. DOI: 10.1038/s41598-019-54392-8
3	Mingming Gao, Xun Huang, Baoliang Song, Hongyuan Yang,The Biogenesis of lipid droplets: Lipids take center stage. Prog Lipid Res. 2019 Jul;75:100989. DOI: 10.1016/j.plipres.2019.100989
4	Mingming Gao, Hongyuan Yang, VPS13: lipid transfer protein making contacts at multiple cellular locations. J Cell Biol. 2018* Oct 1;217(10):3322-3324. DOI: 10.1083/jcb.201808151.
5	Xin Guo#, Mingming Gao#, Yunan Wang#, Xiao Lin, Liu Yang, Nathen Cong, Xiangbo An, Feng Wang, Kai Qu, Liqing Yu, Yuhui Wang, Jinjie Wang, Haibo Zhu, Xunde Xian, George Liu, LDL receptor gene-ablated hamsters: a rodent model of familial hypercholesterolemia with dominant inheritance and diet-induced coronary atherosclerosis. EBioMedicine. 2018 Jan;27:214-224. DOI: 10.1016/j.ebiom.
6	Renhong Yan, Hongwu Qian, Ivan Lukmantara, Mingming Gao, Ximing Du , Nieng Yan, Hongyuan Yang, Human SEIPIN Binds Anionic Phospholipids, Developmental cell, 2018* Oct 22;47(2):248-256.e4. DOI: 10.1016/j.devcel.
7	Jiawei Liao, Xuejing Liu, Mingming Gao, Mengyu Wang, Yuhui Wang, Feng Wang, Wei Huang, George Liu, Dyslipidemia, steatohepatitis and atherogenesis in lipodystrophic apoE deficient mice with Seipin deletion, Gene, 2018; 648: 82-88. DOI: 10.1016/j.gene.

四、团队现有承担课题情况（字体宋体字号三号，加粗）

（一）2019年度河北省高等学校青年拔尖人才计划项目，BJ2019005，AGPAT2缺陷导致脂肪营养不良的机理研究，2019/01-2021/12，9万，主持

（二）国家自然科学基金面上项目，31771306，ORP2在脂肪细胞胆固醇转运中的作用：调节脂肪功能和胰岛素抵抗，2018/01-2021/12，60万，主持

（三）国家自然科学基金青年科学基金，81700386，应用类人化仓鼠模型探讨IDOL在脂代谢和动脉粥样硬化中的作用和机制，2018/01-2020/12，20万，主持

五、团队人员

王晓薇，实验员

1	Mingming Gao, Lin Liu, Xiaowei Wang, Hoi Yin Mak, George Liu, Hongyuan Yang. GPAT3 Deficiency Alleviates Insulin Resistance and Hepatic Steatosis in a Mouse Model of Severe Congenital Generalized Lipodystrophy. Hum Mol Genet. 2020* Feb 1;29(3):432-443. DOI: 10.1093/hmg/ddz300
2	Lin Liu, Chenxi Liang, Xiaowei Wang, Xiayu Ding, Yingjing Lu, Jinghui Dong, Mei Han, Hongyuan Yang, Mingming Gao, Jiawei Liao, Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR-/- mice fed on high-fat diet. Scientific Reports. 2019 Nov 28;9(1):17848. DOI: 10.1038/s41598-019-54392-8
3	Mingming Gao, Xun Huang, Baoliang Song, Hongyuan Yang,The Biogenesis of lipid droplets: Lipids take center stage. Prog Lipid Res. 2019 Jul;75:100989. DOI: 10.1016/j.plipres.2019.100989
4	Mingming Gao, Hongyuan Yang, VPS13: lipid transfer protein making contacts at multiple cellular locations. J Cell Biol. 2018* Oct 1;217(10):3322-3324. DOI: 10.1083/jcb.201808151.
5	Xin Guo#, Mingming Gao#, Yunan Wang#, Xiao Lin, Liu Yang, Nathen Cong, Xiangbo An, Feng Wang, Kai Qu, Liqing Yu, Yuhui Wang, Jinjie Wang, Haibo Zhu, Xunde Xian, George Liu, LDL receptor gene-ablated hamsters: a rodent model of familial hypercholesterolemia with dominant inheritance and diet-induced coronary atherosclerosis. EBioMedicine. 2018 Jan;27:214-224. DOI: 10.1016/j.ebiom.
6	Renhong Yan, Hongwu Qian, Ivan Lukmantara, Mingming Gao, Ximing Du , Nieng Yan, Hongyuan Yang, Human SEIPIN Binds Anionic Phospholipids, Developmental cell, 2018* Oct 22;47(2):248-256.e4. DOI: 10.1016/j.devcel.
7	Jiawei Liao, Xuejing Liu, Mingming Gao, Mengyu Wang, Yuhui Wang, Feng Wang, Wei Huang, George Liu, Dyslipidemia, steatohepatitis and atherogenesis in lipodystrophic apoE deficient mice with Seipin deletion, Gene, 2018; 648: 82-88. DOI: 10.1016/j.gene.